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芳基环己胺

维基百科,自由的百科全书
苯环己哌啶,最常见的芳基环己胺衍生物

芳基环己胺衍生物(英語:Arylcyclohexylamine、arylcyclohexamines或arylcyclohexanamines)是一类含氮有机化合物,常用作药品狡詐家藥物试验药物,其特点是环己烷的一个碳原子上连接了氨基的N原子芳香基,常见的有乙环利定苯环己哌啶[1]

芳基环己胺的各个取代基
从左至右依次是4-甲基-PCP、4'-甲基-PCP、4''-甲基-PCP

化合物

[编辑]
结构 化合物 分子式 芳香基团 含N取代基 环己烷侧取代基 CAS编号
PCA[2] C12H17N 苯基 NH2 - 1934-71-0
PCM[2] C13H19N 苯基 甲氨基 - 2201-16-3
乙环利定(PCE) C14H21N 苯基 乙氨基 - 2201-15-2
PCPr[3] C15H23N 苯基 正丙氨基 - 18949-81-0
PCiP C15H23N 苯基 异丙氨基 - 1195-42-2
PCAL [4] C15H21N 苯基 烯丙氨基 - 2185-95-7
PCBu C16H25N 苯基 正丁氨基 - 73166-29-7
PCEOH C14H21NO 苯基 羟乙氨基 - 2201-22-1
PCMEA[5] C15H23NO 苯基 甲氧乙氨基 - 2201-57-2
PCEEA C16H25NO 苯基 乙氧乙氨基 - 1072895-05-6
PCMPA C16H25NO 苯基 甲氧丙氨基 - 2201-58-3
PCDM[2] C14H21N 苯基 二甲氨基 - 2201-17-4
二乙环利定英语Dieticyclidine(PCDE) C16H25N 苯基 二乙氨基 - 2201-19-6
2-HO-PCP[6] C17H25NO 苯基 哌啶基 2-羟基 94852-58-1
2-Me-PCP[7] C18H27N 苯基 哌啶基 2-甲基 59397-29-4
2-MeO-PCP[8] C18H27NO 苯基 哌啶基 2-甲氧基 78636-34-7
2-Keto-PCP C17H23NO 苯基 哌啶基 2-酮 101688-16-8
2-氧代-PCE("O-PCE") C14H19NO 苯基 乙氨基 2-酮 6740-82-5
2-Keto-PCPr C15H21NO 苯基 正丙氨基 2-酮
4-Methyl-PCP C18H27N 苯基 哌啶基 4-甲基 19420-52-1
4-Keto-PCP[9] C17H23NO 苯基 哌啶基 4-酮 65620-13-5
2'-Cl-PCP C17H24ClN 邻氯苯基 哌啶基 - 2201-31-2
3'-Cl-PCP C17H24ClN 间氯苯基 哌啶基 - 2201-32-3
2'-MeO-PCP C18H27NO 邻甲氧基苯基 哌啶基 - 2201-34-5
3'-F-PCP[10] C17H24FN 间氟苯基 哌啶基 - 89156-99-0
3-甲基苯环己哌啶(3'-Me-PCP)[11] C18H27N 间甲苯基 哌啶基 - 2201-30-1
3'-Me-PCPy C17H25N 间甲苯基 吡咯基 - 1622348-63-3
3'-NH2-PCP C17H26N2 间氨基苯基 哌啶基 - 72242-00-3
3-羥基苯環己哌啶(3'-HO-PCP) C17H25NO 间羟基苯基 哌啶基 - 79787-43-2
3-甲氧基苯環己哌啶(3'-MeO-PCP) C18H27NO 间甲氧基苯基 哌啶基 - 72242-03-6
3',4'-MD-PCP C18H25NO2 3,4-亚甲二氧基苯基 哌啶基 -
3'-MeO-PCE C15H23NO 间甲氧基苯基 乙氨基 - 1364933-80-1
3'-HO-PCE 间羟基苯基 乙氨基 -
3'-MeO-PCPr 间甲氧基苯基 正丙氨基 - 1364933-81-2
3'-HO-PCPr 间羟基苯基 正丙氨基 -
3',4'-MD-PCPr 3,4-亚甲二氧基苯基 正丙氨基 -
3'-MeO-PCPy[11] 间甲氧基苯基 吡咯基 - 1364933-79-8
4-羥基苯環己哌啶(4'-HO-PCP) C17H25NO 对羟基苯基 哌啶基 - 66568-88-5
4-甲氧基苯環己哌啶(4'-MeO-PCP) C18H27NO 对甲氧基苯基 哌啶基 - 2201-35-6
4'-MeO-PCE 对甲氧基苯基 乙氨基 -
4'-F-PCP[10] p-Fluorophenyl 哌啶基 - 22904-99-0
4'-F-PCPy p-Fluorophenyl 吡咯基 -
Arketamine C13H16ClNO 邻氯苯基 甲氨基 2-酮 33643-49-1
Deschloroketamine C13H17NO 苯基 甲氨基 2-酮 7063-30-1
Esketamine C13H16ClNO 邻氯苯基 甲氨基 2-酮 33643-46-8
氯胺酮 C13H16ClNO 邻氯苯基 甲氨基 2-酮 6740-88-1
Hydroxynorketamine C12H14ClNO2 邻氯苯基 NH2 2-酮,6-羟基 81395-70-2
Ethketamine C14H18ClNO 邻氯苯基 乙氨基 2-酮 1354634-10-8
NPNK C15H20ClNO 邻氯苯基 正丙氨基 2-酮 2749326-65-4
Methoxyketamine C14H19NO2 邻甲氧基苯基 甲氨基 2-酮 7063-51-6
2-MeO-NEK[12] C15H21NO2 邻甲氧基苯基 乙氨基 2-酮
oMDCK[13] C14H19NO 邻甲苯基 甲氨基 2-酮 7063-37-8
mMDCK C14H19NO 间甲苯基 甲氨基 2-酮
meta-Ketamine C13H16ClNO 间氯苯基 甲氨基 2-酮 7063-53-8
iso-Ketamine C13H16ClNO 邻氯苯基 甲氨基 4-酮
氟胺酮 C13H16FNO 邻氟苯基 甲氨基 2-酮 111982-50-4
3-氟脱氯氯胺酮 C13H16FNO 间氟苯基 甲氨基 2-酮 2657761-23-2
Bromoketamine 邻溴苯基 甲氨基 2-酮 120807-70-7
TFMDCK o-Trifluoromethylphenyl 甲氨基 2-酮 1782149-73-8
SN 35210[14] 邻氯苯基 Carbomethoxybutylamino 2-酮 1450615-41-4
Methoxetamine C15H21NO2 间甲氧基苯基 乙氨基 2-酮 1239943-76-0
Methoxmetamine C14H19NO2 间甲氧基苯基 甲氨基 2-酮 1781829-56-8
Methoxpropamine C16H23NO2 间甲氧基苯基 正丙氨基 2-酮 2504100-71-2
MXiPr C16H23NO2 间甲氧基苯基 异丙氨基 2-酮
Ethoxetamine C16H23NO2 间乙氧基苯基 乙氨基 2-酮
Deoxymethoxetamine (3-Me-2'-Oxo-PCE) 间甲苯基 乙氨基 2-酮 2666932-45-0
Br-MXE 2-溴-5-甲氧基苯基 乙氨基 2-酮
Hydroxetamine (HXE) 间羟基苯基 乙氨基 2-酮 1620054-73-0
HXM 间羟基苯基 甲氨基 2-酮
2F-NENDCK英语2F-NENDCK C14H18FNO 邻氟苯基 乙氨基 2-酮
Fluorexetamine英语Fluorexetamine (FXE) C14H18FNO 间氟苯基 乙氨基 2-酮
苯环己哌啶(PCP) C17H25N 苯基 哌啶 - 77-10-1
PC3MP C18H27N 苯基 3-甲基哌啶基 - 2201-41-4
PC4MP C18H27N 苯基 4-甲基哌啶基 - 2201-42-5
咯环利定英语Rolicyclidine(PCPy) C16H23N 苯基 吡咯基 - 2201-39-0
PCDMPy C18H27N 苯基 3,3-二甲基吡咯基 -
PCMo C16H23NO 苯基 吗啉基 - 2201-40-3
Methoxy-PCM[15] (2'-MeO-PCMo) 邻甲氧基苯基 Morpholine - 1314323-88-0
3'-MeO-PCMo 间甲氧基苯基 Morpholine - 138873-80-0
4'-MeO-PCMo 对间甲氧基苯基 Morpholine -
Methyl-PCM[16] (4'-Me-PCMo) 对甲苯基 Morpholine - 120803-52-3
Hydroxy-methyl-PCM 2-Methyl-4-hydroxyphenyl Morpholine - 1314323-89-1
PYCP [17] 2-Pyridinyl 哌啶基 -
TCM 2-噻吩基 甲氨基 - 139401-07-3
TCE 2-噻吩基 乙氨基 - 101589-62-2
TCPr [18] 2-噻吩基 正丙氨基 -
Tenocyclidine (TCP) 2-噻吩基 哌啶基 - 21500-98-1
T3CP 3-噻吩基 哌啶基 - 19420-50-9
TCPy 2-噻吩基 吡咯基 - 22912-13-6
Tiletamine 2-噻吩基 乙氨基 2-酮 14176-49-9
MXTE 4-Methoxy-2-thienyl 乙氨基 2-酮
Gacyclidine 2-噻吩基 哌啶基 2-Methyl 68134-81-6
BDPC p-Bromophenyl Dimethylamino 4-Phenethyl-4-hydroxy 77239-98-6
C-8813 p-Bromophenyl Dimethylamino 4-(thiophen-2-yl)ethyl-4-hydroxy 616898-54-5
Dimetamine[19] 对甲苯基 Dimethylamino 4-酮 65619-06-9
3''-OH-2'-Me-PCP [20] C18H27NO 邻甲苯基 3-Hydroxypiperidine -
4''-Ph-4''-OH-PCP [21] 苯基 4-Phenyl-4-hydroxypiperidine - 77179-39-6
BTCP[22] Benzothiophen-2-yl 哌啶基 - 112726-66-6
BTCPy[23] Benzothiophen-2-yl 吡咯基 -
GK-189[24] Naphthalen-2-yl 哌啶基 - 81490-58-6

参考文献

[编辑]
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